This publication reviews the designation of “evidence-based” to describe prevention approaches; examines the evolution of the use of evidence-based in the National Registry of Effective Programs & Practices (NREPP); explores how the recent changes to NREPP have impacted the process that providers use to select interventions to meet the needs of the community they serve; and describes the three categories of evidence-based interventions required by the Strategic Prevention Framework State Incentive Grant (SPF SIG) program.