In substance use disorder (SUD) primary prevention, risk and protective factors play a crucial role in successfully addressing harmful and risky health behaviors. As defined by the Substance Abuse and Mental Health Services Administration (SAMHSA), risk and protective factors “influence the likelihood that an individual will develop a substance misuse or related mental health problem.”1 Once a community has identified priority problem behaviors (e.g., cannabis use, binge drinking, etc.) to address, the risk and protective factors that most significantly influence those priority problem behaviors must be identified. It is also possible to address multiple problem behaviors simultaneously. Find out how!