The California Department of Health Care Services (DHCS), in alignment with the U.S. Department of Health and Human Services, Substance Abuse and Mental Health Services Administration (SAMHSA), is prioritizing integration and coordination of prevention services in public health, mental health, social services, juvenile justice, and education for youth and families with multiple areas of need.  This Tactic highlights two counties in California that are implementing cross-sector collaboration in unique ways. Using diverse strategies, these communities are creating innovative programs and notable outcomes despite our current climate of budgetary restrictions. The Tactic also provides recommendations and resources to support communities in strengthening cross-sector collaboration on a local level.